Graduate Courses » 60535

60535 - Medicinal Chemistry

The practice of drug design as a discipline at the biological chemistry

interface. The topics covered in this course include the synthesis &

purification of drug-like molecules; proof of structure; nomenclature;

intellectual property; drug likeness; hit discovery and the hit-to-lead

transition; the interpretation of the biological data of drug interaction

with enzymes, receptors, and ion channels; the physical organic principles

governing the thermodynamics of drug binding to macromolecules;

structure-activity relationships; and the pharmacology of the adsorption,

disposition, metabolism, excretion, and safety of drugs.